Keratins determine network stress responsiveness in reconstituted actin–keratin filament systems
نویسندگان
چکیده
Reconstituted F-actin/K8–K18 composite filament networks show increasing non-linear strain stiffening, which is induced and dominated by the keratin content.
منابع مشابه
Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro
To investigate the sequences important for assembly of keratins into 10-nm filaments, we used a combined approach of (a) transfection of mutant keratin cDNAs into epithelial cells in vivo, and (b) in vitro assembly of mutant and wild-type keratins. Keratin K14 mutants missing the nonhelical carboxy- and amino-terminal domains not only integrated without perturbation into endogenous keratin fila...
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متن کاملCytoskeletal Filament Systems
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ژورنال
عنوان ژورنال: Soft Matter
سال: 2021
ISSN: ['1744-683X', '1744-6848']
DOI: https://doi.org/10.1039/d0sm02261f